Doctoral Students
Work Package - Ultrasound & Solid Nanoparticles for Viral Delivery

Claudia Hill
Claudia Hill

Claudia joined BUBBL under the supervision of Professor Robert Carlisle upon completion of her MEng in General Engineering at the University of Oxford. She is currently a first year DPhil student working on modifying oncolytic viruses for their enhanced delivery with ultrasound within Work Package 1 of OxCD3 . Specifically, Claudia is looking at using polymers to coat Vaccinia virus to improve its systemic delivery, and using ultrasound to improve its overall tumour penetration and distribution.
Prateek Katti

Prateek is a MD-PhD student and NIH Oxford-Cambridge Scholar, completing his graduate-entry medical training at the University of North Carolina at Chapel Hill and his D. Phil at the University of Oxford as sponsored by the National Institutes of Health (NIH, USA Government). At Oxford and within Work Package One (WP1), he is working at the interface of medical engineering and onco-immunotherapy, aiming to enhance ultrasound-mediated intratumoral delivery of immunotherapeutic antibodies to potentiate anti-tumor immunity. He is co-advised by Prof. Constantin Coussios and Prof. Robert Carlisle along with supervision by prominent investigators from Oxford’s Nuffield Department of Surgical Sciences (NDS) and the NIH.  Prateek attended the Commonwealth Honors College of the University of Massachusetts. Within four years he earned B.S. degrees in Chemical Engineering and Biochemistry & Molecular Biology and was inducted into Tau Beta Pi. He graduated summa cum laude in both disciplines and completed an interdisciplinary honors thesis exploring the mechanical cues of breast cancer tumorigenesis under the direction of Prof. Alfred Crosby and Prof. Shelly Peyton. 
Cameron Smith

Cameron graduated from Imperial College London with first class honours in Biomedical Engineering (MEng).  His final year project was under the supervision of Dr James Choi, developing an acoustic monitoring technique to allow for the measurement of the velocity distribution of microbubbles. As a OxCD3-funded University of Oxford doctoral student, Cameron's current work explores real time monitoring of ultrasound mediated drug delivery. It is hoped that his work will allow for improved monitoring of ultrasound therapies making it easier to bring them to a clinical setting.
Work Package: US-triggered liposomes for the delivery of radiopharmaceuticals

Irini Skaripa-Koukelli

Irini graduated from King’s College London in 2014 with a Master’s in Pharmacy (MPharm) degree. Throughout this course, she undertook a summer research project in medicinal chemistry as well as a final year project on the fabrication and characterisation of biodegradable polymeric nanoparticles for drug delivery.  Irini graduated from the National and Kapodistrian University of Athens in 2011 with a Bachelor’s degree in Chemistry. For this course, she worked in organic chemistry and biochemistry labs. Supported by the EPSRC OxCD3 grant, Irini joined the Department of Oncology in October 2015 to undertake a DPhil project co-supervised by Professors Katherine Vallis and Robert Carlisle from the Institute of Radiation Oncology and BUBBL, respectively. Her project is aimed at exploiting the lactate shuttling through the monocarboxylate transporter for ultrasound-triggered targeted radiotherapy (TRT). Irini is a graduate student at St Cross college.
Jamie Wallis

Jamie graduated from the University of Essex in 2015 with a First class Honours degree in Mathematical sciences including a year abroad at the University of New Mexico, USA. He completed a final year project titled “Analysis of discrete-time biased and correlated random walks” under the supervision of Professor Edward Codling. In September 2015, Jamie then joined the University of Oxford on the Synthetic Biology Doctoral Training Programme.  In October 2016, Jamie joined the BUBBL group as a DPhil candidate, under the supervision of Professor Robert Carlisle and Professor Len Seymour in Oncology, continuing his research into the development of synthetic vaccines.
Work Package: Shock wave delivery of antibody fragments

Alexander Martin

Alex graduated from Ulster University, Northern Ireland, in 2017 with a BSc (Hons) Biomedical Engineering degree with Diploma in Professional Practice, first class honours and distinction, respectively.  Over the course of his degree he performed research in electrochemistry based sensor devices and for his dissertation, researched and developed microneedle arrays for drug delivery and sensing applications under the supervision of Professor James Davis. Receiving the Oxford Centre for Drug Delivery Devices studentship, Alex joined BUBBL and Wadham College as a DPhil candidate in October 2017 and is under the supervision of Professor Robin Cleveland and Professor Robert Carlisle. The main focus of his research is optimising the delivery and uptake of cancer therapeutics using ultrasound and cavitation nuclei.  
Work Package 4: siRNA Delivery for Targeted Imaging and Therapy of Brain Metastases

Luke Richards

Luke  graduated the University of Oxford with an MEng in general engineering. Projects in Luke's undergraduate degree included a study of how HIFU could be used to occlude a major artery, and development of a device to manipulate magnetic nanoparticles. Luke began his DPhil in October 2016 under the supervision of Eleanor Stride and Robin Cleveland. Luke is part of an OxCD3 project to improve drug delivery to brain metastases, and is interested in the effective use of low intensity ultrasound in the human brain and skull.
   
Oliver Vince

Oliver joined BUBBL under the supervision of Professor Eleanor Stride upon completion of his MEng in Engineering Science from the University of Oxford. Oliver’s work has focused on developing a therapy for brain metastases using unfocused ultrasound and antibody targeted microbubbles. He has also investigated how microbubbles influence cell membrane properties and used these findings to develop a microbubble formulation optimised for therapy in the brain. Oliver has been awarded the Leathersellers’ Company Sciences Scholarship and the the Insitute of Engineering and Technology’s Postgraduate Scholarship for an Outstanding Researcher in recognition of his work. .

 

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